unmet need

Patients with psoriasis experience burden that is beyond skin deep. A number of observational studies and patient surveys showed that not all patients with moderate-to-severe psoriasis are achieving clear skin, which can impact their quality of life. Better understanding of the complex immunopathologic circuitry in psoriasis is needed.

Patients with moderate‑to‑severe psoriasis are not achieving clear or almost clear skin

Despite therapeutic advancements, a global patient survey of 8,338 participants completing validated instruments showed that approximately 57% of surveyed patients who are being treated for moderate-to-severe psoriasis have not achieved self-assessed clear/almost clear skin. Of those failing to meet their goals of treatment, the majority (56%) did not think it was possible to achieve the desired level of skin clearance.1

57% of patients being treated for moderate-to-severe plaque psoriasis did not feel that they were achieving clear/almost clear skin.1

Of these, 56% did not think it was possible to achieve the desired level of skin clearance.1

Level of skin clearance is correlated with improvements in quality of life

Patients with poorly controlled psoriasis often experience discrimination and/or humiliation due to their condition, including negative social interactions and lifestyle disruptions.194% of patients with moderate‑to‑severe psoriasis felt that their psoriasis imparted a moderate, large, or very large effect on quality of life as demonstrated by a cross-sectional online quantitative survey targeting adult patients in the USA (N = 500).2 Many live in fear of the next flare-up. Given the impact of psoriasis on patients’ quality of life, the level of skin clearance is an outcome of interest for patients.1


Better understanding of the inflammatory circuit in psoriasis have led to targeted biologic treatments that inhibit key cytokines, including IL-17A, IL-12/IL-23, and TNFα.3 Despite these advances, a multinational, prospective, observational study involving 846 patients indicated that patient needs were still not being met.4More clarity is still needed on the pathogenesis of psoriasis.

mechanism of disease

Alleviating the burden of psoriasis first begins with understanding the science.

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